FAM89A

Across TCGA pan-cancer cohorts, FAM89A RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of FAM89A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where FAM89A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FAM89A is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

HNSC, KIRC, and COAD are the cancer types where FAM89A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM89A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+2.346	<.001	12	view →
KIRC	All	IV	−0.833	<.001	12	view →
COAD	Female	II,III,IV	+1.859	<.001	11	view →
KICH	All	III,IV	−2.855	<.001	10	view →
KIRP	All	All	−1.246	<.001	9	view →
UCEC	All	All	−1.279	<.001	8	view →
STAD	Male	All	+0.949	<.001	7	view →
LUAD	Female	All	−0.912	<.001	7	view →
THCA	All	All	+0.419	<.001	7	view →
BRCA	All	III,IV	−2.158	<.001	6	view →
CHOL	All	All	+1.732	.001	5	view →
READ	All	All	+1.599	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

FAM89A–HNSC

Open the HNSC breakdown →