FAM86JP

Across TCGA pan-cancer cohorts, FAM86JP RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of FAM86JP’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where FAM86JP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FAM86JP is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

HNSC, THCA, and COAD are the cancer types where FAM86JP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM86JP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+1.620	<.001	11	view →
THCA	Male	All	−0.767	<.001	11	view →
COAD	Male	III,IV	+0.826	<.001	10	view →
LUAD	Female	III,IV	+1.205	<.001	9	view →
LIHC	Male	All	+1.155	<.001	9	view →
STAD	Male	II,III,IV	+0.940	<.001	9	view →
LUSC	Female	II,III,IV	+2.034	<.001	8	view →
BRCA	All	III,IV	+0.685	<.001	8	view →
KIRC	Male	II,III,IV	−0.587	<.001	8	view →
KICH	Male	II,III,IV	−1.005	<.001	7	view →
CHOL	Male	All	+1.628	<.001	5	view →
BLCA	All	All	+0.744	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

FAM86JP–HNSC

Open the HNSC breakdown →