FAM86C1P

Across TCGA pan-cancer cohorts, FAM86C1P RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of FAM86C1P’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where FAM86C1P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FAM86C1P is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

HNSC, STAD, and COAD are the cancer types where FAM86C1P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM86C1P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.901	<.001	11	view →
STAD	Male	II,III,IV	+1.301	<.001	10	view →
COAD	Male	III,IV	+0.692	<.001	10	view →
BLCA	All	All	+0.600	<.001	10	view →
LUAD	Female	III,IV	+1.126	<.001	9	view →
LIHC	All	II,III,IV	+0.912	<.001	9	view →
KICH	Female	III,IV	−1.133	<.001	8	view →
LUSC	Female	II,III,IV	+1.128	<.001	7	view →
BRCA	All	III,IV	+0.710	<.001	6	view →
UCEC	All	III,IV	+0.598	.003	6	view →
KIRP	All	II,III,IV	+0.338	.005	5	view →
CHOL	Male	All	+1.800	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

FAM86C1P–HNSC

Open the HNSC breakdown →