FAM83H

Across TCGA pan-cancer cohorts, FAM83H mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of FAM83H’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where FAM83H mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types FAM83H is over-expressed in tumor.

LSCC, LUAD, and PDAC are the cancer types where FAM83H tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM83H mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	III,IV	+1.113	<.001	9	view →
LUAD	All	II,III,IV	+0.350	<.001	8	view →
PDAC	All	All	+0.270	.002	8	view →
COAD	Male	II,III,IV	+0.213	<.001	8	view →
CCRCC	All	All	+0.126	.001	4	view →
HNSC	Female	IV	+0.535	.017	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

FAM83H–LSCC

Open the LSCC breakdown →