FAM83F

Across TCGA pan-cancer cohorts, FAM83F RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of FAM83F’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where FAM83F RNA is repressed in tumor relative to normal tissue. In most cancer types FAM83F is over-expressed in tumor, although a few such as KIRP and KIRC show the opposite, repressed pattern.

KIRP, KIRC, and LUAD are the cancer types where FAM83F tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM83F RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Female	II,III,IV	−2.182	<.001	11	view →
KIRC	Male	II,III,IV	−1.259	<.001	11	view →
LUAD	Male	All	+1.012	<.001	9	view →
LUSC	Female	All	+3.080	<.001	8	view →
THCA	Female	All	−0.622	<.001	7	view →
KICH	Female	II,III,IV	+1.524	<.001	6	view →
HNSC	Male	All	+0.552	.014	4	view →
LIHC	Male	All	−0.565	<.001	3	view →
BRCA	Female	All	−0.299	.019	3	view →
UCEC	All	All	+0.848	.003	2	view →
PRAD	All	All	−0.347	.012	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

FAM83F–KIRP

Open the KIRP breakdown →