FAM83D

Across TCGA pan-cancer cohorts, FAM83D Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FAM83D data layer compared with 28 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher FAM83D Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated FAM83D expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

KIRP, KIRC, and STAD are the cancer types where FAM83D Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.038	0.920	<.001	22	view →
KIRC	OS	Median	All	0.138	0.655	.021	12	view →
STAD	OS	Median	II,III,IV	0.003	0.660	<.001	12	view →
SCLC	OS	Median	All	0.082	0.822	<.001	6	view →
UCEC	DFS	Median	All	0.944	0.624	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FAM83D–KIRP (DFS)

Open the KIRP breakdown →