FAM83D

Across TCGA pan-cancer cohorts, FAM83D mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of FAM83D’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where FAM83D mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types FAM83D is over-expressed in tumor, although a few such as HNSC show the opposite, repressed pattern.

HNSC, LSCC, and LUAD are the cancer types where FAM83D tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM83D mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	−0.708	<.001	11	view →
LSCC	Male	III,IV	+1.252	<.001	8	view →
LUAD	All	All	+0.517	.002	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

FAM83D–HNSC

Open the HNSC breakdown →