FAM83D

Across TCGA patient cohorts, FAM83D mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM83D-associated genes across cancer lineages are NF-kB-p65_pS536, p38-MAPK_pT180_Y182, and Src_pY416. Each is linked with FAM83D in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM83D-to-partner and partner-to-FAM83D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NF-kB-p65_pS536 grouped by FAM83D-low versus FAM83D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM83D→partner) and Y-score (partner→FAM83D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NF-kB-p65_pS536 →	-0.408	-2.999	.040	.035	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.687	-3.584	<.001	.002	3	2
UCEC	Src_pY416 →	-0.222	-2.102	.034	.019	3	2
UCEC	Src_pY527 →	-0.438	-2.311	.019	.034	3	2
UCEC	YB-1_pS102 →	-0.177	-2.115	.028	.019	3	2
UCEC	C-Raf →	+0.151	+2.115	.015	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

NF-kB-p65_pS536 by FAM83D expression — UCEC

Explore this box plot interactively →