FAM83B

Across TCGA pan-cancer cohorts, FAM83B Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated FAM83B data layer compared with 21 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher FAM83B Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated FAM83B expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

COAD, UCEC, and READ are the cancer types where FAM83B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	IV	0.045	0.659	<.001	29	view →
UCEC	DFS	Median	All	0.859	0.613	.001	26	view →
READ	OS	Median	III,IV	0.111	0.903	<.001	24	view →
OV	OS	Median	II,III,IV	0.327	0.693	.006	18	view →
LUAD	DFS	Median	All	0.351	0.693	<.001	13	view →
BLCA	DFS	Median	All	1.000	0.607	.017	10	view →
SARC	DFS	Median	All	0.121	0.591	.042	3	view →
STAD	OS	Median	III,IV	0.163	0.527	.031	3	view →
SKCM	DFS	Median	IV	1.000	0.201	.047	3	view →
HNSC	OS	Median	All	1.000	0.746	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

FAM83B–COAD (OS)

Open the COAD breakdown →