FAM81A

Across TCGA patient cohorts, FAM81A mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM81A-associated genes across cancer lineages are Notch1, PEA-15, and STAT3_pY705. Each is linked with FAM81A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM81A-to-partner and partner-to-FAM81A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by FAM81A-low versus FAM81A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM81A→partner) and Y-score (partner→FAM81A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.187	+2.232	<.001	.005	3	2
UCEC	PEA-15 →	+0.134	+2.321	.043	.033	3	2
UCEC	STAT3_pY705 →	-0.483	-2.392	<.001	<.001	3	2
UCEC	ASNS →	+0.475	+2.584	<.001	.010	3	2
UCEC	c-Met →	-0.227	-2.392	.032	<.001	3	2
UCEC	C-Raf →	+0.211	+3.000	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

Notch1 by FAM81A expression — UCEC

Explore this box plot interactively →