FAM74A7

Across TCGA pan-cancer cohorts, FAM74A7 RNA is linked to patient survival in 10 of 34 cancer types, making it the most broadly survival-associated FAM74A7 data layer compared with 1 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher FAM74A7 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated FAM74A7 expression acts as an unfavorable survival marker, although some lineages such as TGCT show a favorable association.

KIRC, LUSC, and LIHC are the cancer types where FAM74A7 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	III,IV	0.386	0.678	<.001	93	view →
LUSC	OS	Tertile	II,III,IV	0.158	0.748	<.001	72	view →
LIHC	DFS	Tertile	II,III,IV	0.096	0.435	<.001	63	view →
OV	DFS	Tertile	IV	0.163	0.474	.004	54	view →
ACC	DFS	Tertile	All	0.089	0.666	.010	27	view →
LGG	OS	Tertile	All	0.778	0.903	.002	18	view →
LUAD	DFS	Tertile	IV	0.333	0.671	.048	18	view →
STAD	DFS	Tertile	IV	0.083	0.379	.001	9	view →
BRCA	OS	Tertile	II,III,IV	0.876	0.959	.041	6	view →
TGCT	DFS	Median	II,III,IV	1.000	0.772	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

FAM74A7–KIRC (DFS)

Open the KIRC breakdown →