FAM71D

Across TCGA pan-cancer cohorts, FAM71D Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated FAM71D data layer compared with 19 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher FAM71D Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated FAM71D expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

ESCA, UCEC, and LIHC are the cancer types where FAM71D Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	DFS	Median	II,III,IV	0.082	0.523	<.001	12	view →
UCEC	OS	Median	All	0.968	0.643	.020	8	view →
LIHC	OS	Median	All	0.083	0.783	<.001	6	view →
SKCM	OS	Median	All	0.183	0.345	.026	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

FAM71D–ESCA (DFS)

Open the ESCA breakdown →