FAM71C

Across TCGA pan-cancer cohorts, FAM71C RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of FAM71C’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where FAM71C RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FAM71C is over-expressed in tumor, although a few such as THCA and READ show the opposite, repressed pattern.

BRCA, KIRP, and THCA are the cancer types where FAM71C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM71C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	All	+0.139	.017	4	view →
KIRP	Female	II,III,IV	+0.064	.018	4	view →
THCA	Female	All	−0.054	<.001	4	view →
KIRC	Male	All	+0.018	.018	4	view →
READ	All	II,III,IV	−0.035	.031	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

FAM71C–BRCA

Open the BRCA breakdown →