FAM71B

Across TCGA patient cohorts, FAM71B mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible FAM71B-associated genes across cancer lineages are TFRC, ERK2, and p27. Each is linked with FAM71B in more than 3 cancer types. Because this analysis shows association rather than direction, both FAM71B-to-partner and partner-to-FAM71B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by FAM71B-low versus FAM71B-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM71B→partner) and Y-score (partner→FAM71B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	TFRC →	+0.717	+1.709	.006	.026	3	4
LUSC	ERK2 →	+0.252	+3.000	.025	.035	3	3
LUSC	p27 →	-0.207	-3.445	<.001	.005	3	3
UCEC	Notch1 →	+0.113	+1.598	.011	.019	3	3
UCEC	C-Raf →	+0.160	+1.662	<.001	.010	3	3
UCEC	Cyclin-B1 →	+0.514	+1.906	.004	.015	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

TFRC by FAM71B expression — LUSC

Explore this box plot interactively →