FAM71B

Across TCGA cell cohorts, FAM71B mutation is significantly associated with the RNA expression of many other genes, with 45 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible FAM71B-associated genes across cancer lineages are SMIM9, IAPP, and NKX2-4. Each is linked with FAM71B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM71B-to-partner and partner-to-FAM71B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMIM9 grouped by FAM71B-low versus FAM71B-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM71B→partner) and Y-score (partner→FAM71B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SMIM9 →	+0.022	+4.029	<.001	.007	3	2
LARGE_INTESTINE	IAPP →	+0.412	+3.228	<.001	.003	3	2
PANCREAS	NKX2-4 →	+0.007	+4.652	<.001	<.001	3	1
PANCREAS	POU4F2 →	+0.005	+3.491	<.001	.008	3	1
PANCREAS	ZSWIM2 →	+0.018	+4.139	.005	.001	3	1
PANCREAS	IL3 →	+0.014	+4.029	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

SMIM9 by FAM71B expression — PANCREAS

Explore this box plot interactively →