FAM53C

Across TCGA pan-cancer cohorts, FAM53C mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated FAM53C data layer compared with 22 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher FAM53C mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated FAM53C expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

LUAD and HNSC are the cancer types where FAM53C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.881	0.397	.013	5	view →
HNSC	OS	Median	II,III,IV	0.902	0.686	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

FAM53C–LUAD (DFS)

Open the LUAD breakdown →