FAM53C

Across TCGA patient cohorts, FAM53C mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM53C-associated genes across cancer lineages are Heregulin, INPP4B, and JNK2. Each is linked with FAM53C in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM53C-to-partner and partner-to-FAM53C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heregulin grouped by FAM53C-low versus FAM53C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM53C→partner) and Y-score (partner→FAM53C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Heregulin →	-0.197	-3.169	<.001	.019	3	1
UCEC	INPP4B →	-0.380	-3.321	.014	.010	3	1
UCEC	JNK2 →	+0.269	+2.817	.005	.036	3	1
UCEC	Ku80 →	+0.332	+3.598	.003	.001	3	1
UCEC	MEK1 →	+0.531	+3.584	.002	.002	3	1
UCEC	SETD2 →	-0.221	-3.169	.035	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Heregulin by FAM53C expression — UCEC

Explore this box plot interactively →