FAM53C

Across TCGA cell cohorts, FAM53C RNA expression is significantly associated with the go_rna of many other GO terms, with 4,315 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FAM53C-associated GO terms across cancer lineages are Negative regulation of chromosome organization, Subtelomeric heterochromatin formation, and Establishment of RNA localization. Each is linked with FAM53C in more than 15 cancer types. Because this analysis shows association rather than direction, both FAM53C-to-partner and partner-to-FAM53C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of chromosome organization grouped by FAM53C-low versus FAM53C-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM53C→partner) and Y-score (partner→FAM53C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of chromosome organization →	+0.127	+1.434	<.001	<.001	3	16
BREAST	Subtelomeric heterochromatin formation →	+0.093	+0.652	.004	.005	3	16
SOFT_TISSUE	Establishment of RNA localization →	+0.109	+1.068	<.001	<.001	3	16
OESOPHAGUS	Establishment of protein localization to organelle →	+0.068	+0.896	<.001	.001	3	16
UPPER_AERODIGESTIVE_TRACT	RNA localization →	+0.084	+1.091	.003	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Protein import into nucleus →	+0.078	+1.074	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,315 associations by consensus.

Negative regulation of chromosome organization by FAM53C expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →