Across TCGA pan-cancer cohorts, FAM53B mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated FAM53B data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher FAM53B mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated FAM53B expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LSCC, LUAD, and GBM are the cancer types where FAM53B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	All	0.835	0.585	.001	19	view →
LUAD	DFS	Tertile	All	0.802	1.000	.020	8	view →
GBM	OS	Median	All	0.371	0.655	.034	5	view →
PDAC	DFS	Quartile	All	0.493	0.868	.035	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: FAM53B tumor-vs-normal RNA expression · all FAM53B data types