Across TCGA patient cohorts, FAM53B mutation is significantly associated with the RNA expression of many other genes, with 2,410 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM53B-associated genes across cancer lineages are RAB28P2, RNA5SP415, and PDCL2P1. Each is linked with FAM53B in more than 2 cancer types. Because this analysis shows association rather than direction, both FAM53B-to-partner and partner-to-FAM53B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM53B→partner) and Y-score (partner→FAM53B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RAB28P2 →	+0.068	+5.438	.003	.002	3	3
LUSC	RNA5SP415 →	+1.086	+5.733	<.001	.001	3	3
CESC	PDCL2P1 →	+0.070	+4.252	<.001	.006	3	2
CESC	RPL21P88 →	+0.094	+3.121	<.001	.004	3	2
CESC	GLYATL1P4 →	+0.378	+4.282	<.001	<.001	3	2
CESC	HIGD1AP9 →	+0.146	+2.806	.003	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,410 associations by consensus.

Exploration

FAM53B survival (RNA) · tumor vs normal (RNA) · all FAM53B data types