Across TCGA patient cohorts, FAM53B mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM53B-associated genes across cancer lineages are JNK2, A-Raf_pS299, and FOXO3a_pS318_S321. Each is linked with FAM53B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM53B-to-partner and partner-to-FAM53B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM53B→partner) and Y-score (partner→FAM53B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.296	+3.331	<.001	.005	3	2
UCEC	A-Raf_pS299 →	-0.213	-3.584	<.001	.002	3	1
UCEC	FOXO3a_pS318_S321 →	-0.131	-2.321	.011	.006	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.576	+3.469	.006	.002	3	1
UCEC	Ku80 →	+0.331	+2.335	<.001	.003	3	1
UCEC	mTOR_pS2448 →	-0.126	-1.807	.040	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Exploration

FAM53B survival (RNA) · tumor vs normal (RNA) · all FAM53B data types