Across TCGA cell cohorts, FAM53B mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FAM53B-associated genes across cancer lineages are CSN1S1, DEFA6, and DMRTC2. Each is linked with FAM53B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM53B-to-partner and partner-to-FAM53B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM53B→partner) and Y-score (partner→FAM53B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CSN1S1 →	+0.041	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	DEFA6 →	+0.164	+5.228	<.001	.005	3	1
BLOOD_Leukemia	DMRTC2 →	+0.031	+5.539	<.001	.003	3	1
BLOOD_Leukemia	GPR6 →	+0.025	+4.922	<.001	.009	3	1
BLOOD_Leukemia	SPHKAP →	+0.006	+4.922	.005	.009	3	1
BLOOD_Leukemia	OR52E4 →	+0.032	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

FAM53B survival (RNA) · tumor vs normal (RNA) · all FAM53B data types