Across TCGA pan-cancer cohorts, FAM47A RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of FAM47A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where FAM47A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FAM47A is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.

HNSC, BRCA, and LUAD are the cancer types where FAM47A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM47A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.022	.001	12	view →
BRCA	All	All	+0.021	.019	6	view →
LUAD	All	All	+0.015	.012	2	view →
LUSC	All	All	+0.008	.012	2	view →
KIRC	Male	All	−0.003	.025	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: FAM47A RNA expression & survival · all FAM47A data types