FAM43B

Across TCGA pan-cancer cohorts, FAM43B Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FAM43B data layer compared with 27 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher FAM43B Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated FAM43B expression acts as an unfavorable survival marker.

ACC, ESCA, and LUAD are the cancer types where FAM43B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.010	0.667	<.001	45	view →
ESCA	DFS	Median	All	0.139	0.538	<.001	30	view →
LUAD	OS	Median	All	0.237	0.788	.008	14	view →
UCEC	OS	Median	IV	0.066	0.755	<.001	12	view →
LUSC	DFS	Median	All	0.216	0.661	.023	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FAM43B–ACC (DFS)

Open the ACC breakdown →