Across TCGA patient cohorts, FAM3D mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM3D-associated genes across cancer lineages are JNK_pT183_Y185, JNK2, and Ku80. Each is linked with FAM3D in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM3D-to-partner and partner-to-FAM3D results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM3D→partner) and Y-score (partner→FAM3D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.215	-3.459	.003	.005	3	1
UCEC	JNK2 →	+0.206	+2.115	.017	.019	3	1
UCEC	Ku80 →	+0.295	+2.128	.004	.010	3	1
UCEC	MEK1 →	+0.451	+3.321	.004	.010	3	1
UCEC	PDCD4 →	-0.560	-3.169	.006	.018	3	1
UCEC	STAT3_pY705 →	-0.460	-2.115	<.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Exploration

FAM3D survival (RNA) · tumor vs normal (RNA) · all FAM3D data types