Across TCGA cell cohorts, FAM3D mutation is significantly associated with the drug of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FAM3D-associated genes across cancer lineages are GSK2801, JNJ38877605, and WHI-P97. Each is linked with FAM3D in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM3D-to-partner and partner-to-FAM3D results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM3D→partner) and Y-score (partner→FAM3D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GSK2801 →	+0.385	+2.649	.014	.046	3	1
LARGE_INTESTINE	JNJ38877605 →	+0.373	+2.786	.031	.037	3	1
LARGE_INTESTINE	WHI-P97 →	+0.564	+2.786	.001	.037	3	1
LARGE_INTESTINE	LIMK1 inhibitor BMS4 →	+0.358	+2.786	.047	.037	3	1
LARGE_INTESTINE	PRIMA-1MET →	+0.563	+2.646	.036	.047	2	1
LARGE_INTESTINE	JAK1_8709 →	+0.393	+2.649	.048	.046	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Exploration

FAM3D survival (RNA) · tumor vs normal (RNA) · all FAM3D data types