Across TCGA pan-cancer cohorts, FAM3C mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of FAM3C’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LSCC), where FAM3C mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types FAM3C is over-expressed in tumor.
LSCC, LUAD, and COAD are the cancer types where FAM3C tumor–normal differential expression is most reproducible.
mass-spec protein tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM3C mass-spec protein (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.