Across TCGA patient cohorts, FAM3C mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM3C-associated genes across cancer lineages are EGFR_pY1068, FoxM1, and INPP4B. Each is linked with FAM3C in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM3C-to-partner and partner-to-FAM3C results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM3C→partner) and Y-score (partner→FAM3C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.295	-3.584	.014	.002	3	1
UCEC	FoxM1 →	+0.274	+2.459	.028	.020	3	1
UCEC	INPP4B →	-0.399	-3.321	.010	.009	3	1
UCEC	JNK2 →	+0.228	+3.009	.017	.019	3	1
UCEC	mTOR →	-0.161	-2.459	.038	.020	3	1
UCEC	Notch1 →	+0.220	+3.179	.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Exploration

FAM3C survival (RNA) · tumor vs normal (RNA) · all FAM3C data types