FAM3A

Across TCGA pan-cancer cohorts, FAM3A Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated FAM3A data layer compared with 23 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher FAM3A Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated FAM3A expression acts as an unfavorable survival marker.

THYM and ACC are the cancer types where FAM3A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	DFS	Median	All	0.092	0.872	<.001	6	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

FAM3A–THYM (DFS)

Open the THYM breakdown →