FAM3A

Across TCGA patient cohorts, FAM3A mutation is significantly associated with the RNA expression of many other genes, with 224 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM3A-associated genes across cancer lineages are ZNF90P3, LINC00624, and IGKV1D-12. Each is linked with FAM3A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM3A-to-partner and partner-to-FAM3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF90P3 grouped by FAM3A-low versus FAM3A-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM3A→partner) and Y-score (partner→FAM3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ZNF90P3 →	+0.042	+5.303	.002	.006	3	2
UCEC	LINC00624 →	+0.607	+3.418	.001	.004	3	1
UCEC	IGKV1D-12 →	+1.264	+4.010	.001	<.001	3	1
BLCA	RNA5SP258 →	+0.388	+7.640	<.001	.009	3	1
BLCA	RNU6-1040P →	+0.343	+7.640	<.001	.009	3	1
BLCA	MIR592 →	+0.418	+7.640	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 224 associations by consensus.

ZNF90P3 by FAM3A expression — HNSC

Explore this box plot interactively →