FAM3A

Across TCGA cell cohorts, FAM3A RNA expression is significantly associated with the go_rna of many other GO terms, with 3,484 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible FAM3A-associated GO terms across cancer lineages are Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, Positive regulation of microtubule nucleation, and Antifungal humoral response. Each is linked with FAM3A in more than 14 cancer types. Because this analysis shows association rather than direction, both FAM3A-to-partner and partner-to-FAM3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway grouped by FAM3A-low versus FAM3A-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM3A→partner) and Y-score (partner→FAM3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway →	+0.111	+1.011	.004	.005	3	15
SKIN	Positive regulation of microtubule nucleation →	+0.132	+0.611	.001	.003	2	14
LARGE_INTESTINE	Antifungal humoral response →	+0.262	+0.891	<.001	<.001	3	12
LUNG_NSCLC_LUAD	Regulation of proteasomal protein catabolic process →	+0.036	+0.702	<.001	.001	3	12
BLOOD_Myeloma	Negative regulation of response to endoplasmic reticulum stress →	+0.109	+0.884	<.001	.005	3	12
LIVER	Mitochondrial gene expression →	-0.086	-1.276	.003	.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,484 associations by consensus.

Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway by FAM3A expression — LUNG_NSCLC_LUSC

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