FAM27E5

Across TCGA pan-cancer cohorts, FAM27E5 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated FAM27E5 data layer compared with 11 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher FAM27E5 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated FAM27E5 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

THYM, BRCA, and SKCM are the cancer types where FAM27E5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
BRCA	OS	Median	All	0.514	0.963	<.001	36	view →
SKCM	OS	Median	All	0.230	0.781	.004	22	view →
HNSC	DFS	Median	All	0.170	0.626	.031	9	view →
LGG	OS	Median	All	0.219	0.889	<.001	8	view →
PRAD	DFS	Median	All	0.200	0.775	.013	6	view →
LUAD	DFS	Median	All	0.873	0.320	.016	4	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

FAM27E5–THYM (OS)

Open the THYM breakdown →