FAM27E5

Across TCGA patient cohorts, FAM27E5 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM27E5-associated genes across cancer lineages are EGFR_pY1068, MSH6, and Shc_pY317. Each is linked with FAM27E5 in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM27E5-to-partner and partner-to-FAM27E5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by FAM27E5-low versus FAM27E5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM27E5→partner) and Y-score (partner→FAM27E5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.323	-3.000	.013	.036	3	1
UCEC	MSH6 →	-0.608	-3.321	<.001	.010	3	1
UCEC	Shc_pY317 →	-0.266	-3.321	<.001	.010	3	1
UCEC	14-3-3_beta →	-0.133	-2.979	.011	.036	2	1
UCEC	Heregulin →	-0.177	-3.000	.006	.036	2	1
UCEC	MSH2 →	-0.396	-2.990	.001	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

EGFR_pY1068 by FAM27E5 expression — UCEC

Explore this box plot interactively →