Across TCGA pan-cancer cohorts, FAM25E RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of FAM25E’s most consistent transcriptional readouts.

The strongest signal is observed in stomach adenocarcinoma (STAD), where FAM25E RNA is repressed in tumor relative to normal tissue. In most cancer types FAM25E is over-expressed in tumor, although a few such as STAD and LUSC show the opposite, repressed pattern.

STAD, KIRC, and LUSC are the cancer types where FAM25E tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM25E RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
STAD	All	All	−0.214	.034	2	view →
KIRC	All	II,III,IV	+0.027	.030	2	view →
LUSC	Female	III,IV	−0.160	.003	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: FAM25E RNA expression & survival · all FAM25E data types