Across TCGA pan-cancer cohorts, FAM243A RNA is linked to patient survival in 4 of 34 cancer types, making it the most broadly survival-associated FAM243A data layer.

The strongest signal is observed in pancreatic adenocarcinoma (PAAD), where higher FAM243A RNA is associated with worse overall survival. In most high-consensus cancer types, elevated FAM243A expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

PAAD, PRAD, and SKCM are the cancer types where FAM243A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PAAD	OS	Tertile	All	0.242	0.615	.009	27	view →
PRAD	OS	Tertile	All	0.850	0.990	<.001	18	view →
SKCM	OS	Tertile	All	1.000	0.312	.040	12	view →
LUSC	OS	Tertile	II,III,IV	0.161	0.677	.015	9	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: FAM243A tumor-vs-normal RNA expression · all FAM243A data types