FAM241B

Across TCGA pan-cancer cohorts, FAM241B mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FAM241B data layer compared with 22 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher FAM241B mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated FAM241B expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

HNSC, LUAD, and LSCC are the cancer types where FAM241B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.754	0.539	.011	25	view →
LUAD	DFS	Median	All	0.922	0.959	.012	12	view →
LSCC	DFS	Quartile	II,III,IV	0.594	0.896	.015	11	view →
CCRCC	DFS	Tertile	III,IV	0.487	0.830	.012	9	view →
GBM	DFS	Tertile	All	0.903	0.626	.006	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FAM241B–HNSC (DFS)

Open the HNSC breakdown →