FAM239A

Across TCGA pan-cancer cohorts, FAM239A RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated FAM239A data layer compared with 1 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher FAM239A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated FAM239A expression acts as an unfavorable survival marker, although some lineages such as STAD and CESC show a favorable association.

ACC, STAD, and THCA are the cancer types where FAM239A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.419	0.728	<.001	58	view →
STAD	OS	Median	IV	0.642	0.194	.003	29	view →
THCA	DFS	Median	All	0.848	0.978	.001	29	view →
LUAD	OS	Median	III,IV	0.201	0.450	.009	19	view →
LIHC	OS	Quartile	II,III,IV	0.511	0.833	.001	19	view →
SKCM	DFS	Quartile	All	0.647	0.812	.011	18	view →
LUSC	DFS	Median	II,III,IV	0.385	0.656	.020	15	view →
CESC	OS	Quartile	IV	0.778	0.305	.035	12	view →
LGG	OS	Median	All	0.926	0.862	.014	9	view →
MESO	DFS	Tertile	III,IV	0.246	0.439	.021	8	view →
UVM	DFS	Median	II,III,IV	0.808	0.435	.021	6	view →
OV	OS	Tertile	II,III,IV	0.897	0.805	.023	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

FAM239A–ACC (DFS)

Open the ACC breakdown →