FAM238A

Across TCGA pan-cancer cohorts, FAM238A RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated FAM238A data layer compared with 2 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher FAM238A RNA is associated with worse overall survival. In most high-consensus cancer types, elevated FAM238A expression acts as an unfavorable survival marker, although some lineages such as SKCM and CESC show a favorable association.

UVM, SKCM, and CESC are the cancer types where FAM238A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	All	0.378	0.698	<.001	122	view →
SKCM	OS	Quartile	All	0.510	0.278	<.001	74	view →
CESC	OS	Quartile	All	0.936	0.816	.010	30	view →
SARC	OS	Quartile	All	0.948	0.787	<.001	25	view →
LUAD	OS	Quartile	All	0.416	0.270	.007	24	view →
KIRC	DFS	Quartile	II,III,IV	0.392	0.678	.010	20	view →
THYM	OS	Quartile	All	1.000	0.701	.005	17	view →
LUSC	OS	Quartile	III,IV	0.779	0.421	.003	16	view →
LGG	DFS	Median	All	0.334	0.445	.001	15	view →
PCPG	OS	Tertile	All	0.784	1.000	.004	13	view →
PAAD	DFS	Tertile	II,III,IV	0.585	0.342	.012	13	view →
MESO	DFS	Tertile	All	0.645	0.252	.016	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

FAM238A–UVM (OS)

Open the UVM breakdown →