FAM234B

Across TCGA pan-cancer cohorts, FAM234B Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated FAM234B data layer compared with 25 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher FAM234B Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated FAM234B expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

ESCA, UCEC, and READ are the cancer types where FAM234B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	DFS	Median	II,III,IV	0.147	0.525	.006	18	view →
UCEC	DFS	Median	All	0.973	0.827	.013	16	view →
READ	OS	Median	All	0.166	0.830	<.001	14	view →
MESO	DFS	Median	III,IV	0.078	0.376	.012	9	view →
COAD	DFS	Median	III,IV	0.005	0.650	<.001	7	view →
THCA	OS	Median	All	0.342	0.955	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

FAM234B–ESCA (DFS)

Open the ESCA breakdown →