FAM234B

Across TCGA patient cohorts, FAM234B mutation is significantly associated with the RNA expression of many other genes, with 4,872 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM234B-associated genes across cancer lineages are PACSIN2, SLC66A2, and LONP1. Each is linked with FAM234B in more than 2 cancer types. Because this analysis shows association rather than direction, both FAM234B-to-partner and partner-to-FAM234B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PACSIN2 grouped by FAM234B-low versus FAM234B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM234B→partner) and Y-score (partner→FAM234B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PACSIN2 →	+0.605	+2.432	<.001	<.001	3	3
UCEC	SLC66A2 →	+0.535	+3.906	<.001	<.001	3	3
UCEC	LONP1 →	+0.654	+2.443	<.001	<.001	3	3
BRCA	MIR633 →	+0.156	+4.162	.002	.009	3	2
UCEC	ARRDC3-AS1 →	+0.302	+2.454	<.001	<.001	3	2
UCEC	CIAO2B →	+0.364	+2.454	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,872 associations by consensus.

PACSIN2 by FAM234B expression — UCEC

Explore this box plot interactively →