FAM234B

Across TCGA patient cohorts, FAM234B mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM234B-associated genes across cancer lineages are mTOR, Notch1, and Rad50. Each is linked with FAM234B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM234B-to-partner and partner-to-FAM234B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR grouped by FAM234B-low versus FAM234B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM234B→partner) and Y-score (partner→FAM234B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR →	-0.141	-1.440	.012	.024	3	2
UCEC	Notch1 →	+0.111	+1.495	.023	.034	3	2
UCEC	Rad50 →	-0.194	-1.736	.021	.007	3	2
UCEC	ASNS →	+0.344	+1.440	.006	.024	3	2
UCEC	ATM →	-0.589	-2.794	<.001	.002	3	2
UCEC	Chk2_pT68 →	-0.155	-3.295	.016	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

mTOR by FAM234B expression — UCEC

Explore this box plot interactively →