FAM234B

Across TCGA cell cohorts, FAM234B mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible FAM234B-associated genes across cancer lineages are PRSS58, OR4A47, and C20orf85. Each is linked with FAM234B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM234B-to-partner and partner-to-FAM234B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRSS58 grouped by FAM234B-low versus FAM234B-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM234B→partner) and Y-score (partner→FAM234B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PRSS58 →	+0.092	+5.000	<.001	.006	3	1
BLOOD_Lymphoma	OR4A47 →	+0.022	+5.643	<.001	.002	3	1
SKIN	C20orf85 →	+0.029	+3.345	<.001	.007	3	1
SKIN	VSIG4 →	+0.014	+3.347	<.001	.005	3	1
SKIN	LMX1A →	+0.046	+3.347	<.001	.005	3	1
SKIN	FEV →	+0.083	+3.823	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

PRSS58 by FAM234B expression — PANCREAS

Explore this box plot interactively →