FAM230I

Across TCGA patient cohorts, FAM230I mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM230I-associated genes across cancer lineages are 14-3-3_beta, FOXO3a, and JNK_pT183_Y185. Each is linked with FAM230I in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM230I-to-partner and partner-to-FAM230I results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by FAM230I-low versus FAM230I-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM230I→partner) and Y-score (partner→FAM230I) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.158	-2.986	.006	.037	3	1
UCEC	FOXO3a →	-0.119	-2.986	.043	.037	3	1
UCEC	JNK_pT183_Y185 →	-0.212	-2.986	.029	.037	3	1
UCEC	Smad4 →	-0.180	-2.980	.009	.036	3	1
UCEC	EGFR_pY1068 →	-0.317	-3.000	.029	.037	2	1
UCEC	ACC_pS79 →	+0.493	+3.000	.013	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

14-3-3_beta by FAM230I expression — UCEC

Explore this box plot interactively →