Across TCGA pan-cancer cohorts, FAM230H RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of FAM230H’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where FAM230H RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FAM230H is over-expressed in tumor.
THCA and LIHC are the cancer types where FAM230H tumor–normal differential expression is most reproducible.