Across TCGA patient cohorts, FAM227A RNA expression is significantly associated with the protein abundance of many other proteins, with 11,923 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible FAM227A-associated proteins across cancer lineages are IFT74, WDR19, and WDR35. Each is linked with FAM227A in more than 6 cancer types. Because this analysis shows association rather than direction, both FAM227A-to-partner and partner-to-FAM227A results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM227A→partner) and Y-score (partner→FAM227A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IFT74 →	+0.471	+0.726	<.001	<.001	3	7
UCEC	WDR19 →	+0.366	+0.676	<.001	<.001	3	5
UCEC	WDR35 →	+0.342	+0.636	<.001	<.001	3	5
LSCC	WDR54 →	+0.421	+0.674	<.001	<.001	3	5
OV	CETN2 →	+0.415	+0.793	.001	.003	3	5
UCEC	IFT140 →	+0.375	+0.597	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,923 associations by consensus.

Exploration

FAM227A survival (RNA) · tumor vs normal (RNA) · all FAM227A data types