Across TCGA patient cohorts, FAM227A mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM227A-associated genes across cancer lineages are ATM, 14-3-3_beta, and eEF2. Each is linked with FAM227A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM227A-to-partner and partner-to-FAM227A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM227A→partner) and Y-score (partner→FAM227A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.638	-3.459	.001	.005	3	2
UCEC	14-3-3_beta →	-0.140	-3.295	.001	.009	3	1
UCEC	eEF2 →	+0.489	+3.321	.001	.009	3	1
UCEC	EGFR_pY1068 →	-0.289	-3.169	.008	.019	3	1
UCEC	A-Raf_pS299 →	-0.172	-3.321	<.001	.010	3	1
UCEC	FOXO3a_pS318_S321 →	-0.118	-2.321	.030	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Exploration

FAM227A survival (RNA) · tumor vs normal (RNA) · all FAM227A data types