Across TCGA cell cohorts, FAM227A mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible FAM227A-associated genes across cancer lineages are OR4A47, ZSWIM2, and SPAG11A. Each is linked with FAM227A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM227A-to-partner and partner-to-FAM227A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM227A→partner) and Y-score (partner→FAM227A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR4A47 →	+0.022	+5.643	<.001	.002	3	2
BLOOD_Lymphoma	ZSWIM2 →	+0.024	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	SPAG11A →	+0.111	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	ZNF705G →	+0.006	+4.867	<.001	.009	3	1
LUNG_NSCLC_LUAD	GPR42 →	+0.016	+4.887	<.001	.009	3	1
SKIN	SHOX →	+0.045	+3.930	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Exploration

FAM227A survival (RNA) · tumor vs normal (RNA) · all FAM227A data types