FAM226B

Across TCGA pan-cancer cohorts, FAM226B RNA is linked to patient survival in 10 of 34 cancer types, making it the most broadly survival-associated FAM226B data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher FAM226B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated FAM226B expression acts as an unfavorable survival marker, although some lineages such as UCS and ESCA show a favorable association.

UVM, KIRC, and SARC are the cancer types where FAM226B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	All	0.075	0.835	<.001	72	view →
KIRC	DFS	Tertile	II,III,IV	0.201	0.775	<.001	42	view →
SARC	DFS	Tertile	All	0.201	0.522	.007	36	view →
CESC	OS	Tertile	All	0.621	0.880	.005	30	view →
SKCM	DFS	Tertile	IV	0.016	0.454	<.001	18	view →
TGCT	DFS	Tertile	All	0.377	0.688	.023	18	view →
LIHC	DFS	Tertile	All	0.134	0.530	.030	18	view →
UCS	DFS	Tertile	III,IV	1.000	0.222	.046	12	view →
GBM	OS	Tertile	All	0.295	0.502	.034	6	view →
ESCA	OS	Median	III,IV	0.692	0.346	.036	4	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

FAM226B–UVM (OS)

Open the UVM breakdown →