FAM225A

Across TCGA pan-cancer cohorts, FAM225A RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated FAM225A data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher FAM225A RNA is associated with worse overall survival. In most high-consensus cancer types, elevated FAM225A expression acts as an unfavorable survival marker, although some lineages such as UCS and SKCM show a favorable association.

ACC, KIRC, and UVM are the cancer types where FAM225A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.375	0.893	<.001	135	view →
KIRC	OS	Median	All	0.532	0.708	<.001	117	view →
UVM	OS	Tertile	All	0.449	0.851	<.001	98	view →
MESO	DFS	Median	All	0.266	0.462	<.001	89	view →
UCS	DFS	Median	III,IV	0.527	0.142	.001	42	view →
KICH	DFS	Quartile	II,III,IV	0.622	1.000	.013	36	view →
THCA	DFS	Median	III,IV	0.772	0.932	.008	29	view →
STAD	DFS	Tertile	All	0.291	0.492	.015	29	view →
KIRP	DFS	Median	III,IV	0.198	0.828	<.001	27	view →
UCEC	DFS	Median	All	0.592	0.683	.010	20	view →
GBM	DFS	Quartile	All	0.222	0.393	.014	12	view →
SKCM	OS	Tertile	IV	0.753	0.273	.003	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

FAM225A–ACC (OS)

Open the ACC breakdown →