FAM223A

Across TCGA pan-cancer cohorts, FAM223A RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated FAM223A data layer.

The strongest signal is observed in thyroid carcinoma (THCA), where higher FAM223A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated FAM223A expression acts as an unfavorable survival marker.

THCA, ACC, and COAD are the cancer types where FAM223A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	DFS	Tertile	II,III,IV	0.323	0.740	<.001	114	view →
ACC	OS	Tertile	All	0.114	0.892	<.001	72	view →
COAD	OS	Tertile	All	0.457	0.873	.002	45	view →
LIHC	DFS	Tertile	III,IV	0.109	0.366	.011	45	view →
BRCA	DFS	Tertile	All	0.239	0.536	.001	36	view →
HNSC	DFS	Tertile	III,IV	0.242	0.599	.007	36	view →
LUSC	OS	Tertile	II,III,IV	0.163	0.687	.002	30	view →
SKCM	DFS	Tertile	III,IV	0.016	0.648	<.001	27	view →
SARC	OS	Tertile	All	0.336	0.750	.003	27	view →
TGCT	OS	Tertile	All	0.814	0.968	.009	18	view →
BLCA	OS	Tertile	IV	0.153	0.587	.011	18	view →
UCEC	DFS	Tertile	IV	0.206	0.704	.033	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

FAM223A–THCA (DFS)

Open the THCA breakdown →